应用超光谱拉曼分子影像显微镜研究活体细胞代谢

发布者:系统管理员发布时间:2014-10-15浏览次数:1077

报告人:王平博士,威尔顿生物医药工程学院,美国普度大学

报告题目:应用超光谱拉曼分子影像显微镜研究活体细胞代谢
Fingerprinting Cell Metabolism by Using Hyperspectral Stimulated Raman Scattering Microscopy

 

报告摘要:

Imaging and quantitation of chemical metabolites in single cells of live animals has been a long-standing obstacle. By hyperspectral stimulated Raman scattering imaging and multivariate analysis in fingerprint vibration region, we present a platform that allows quantitative mapping of fat distribution, degree of fat unsaturation, lipid oxidation, and cholesterol storage in vivo in whole C. elegans with submicron resolution. Our results reveal for the first time that lysosome related organelles in intestinal cells are sites for storage of cholesterol in C. elegans.

 

研究背景及教育经历:

20121至今,

威尔顿生物医药工程学院,美国普度大学(Purdue University Postdoctoral Researcher Associate  

20111- 201112,

化学系分析化学美国普度大学 Research Scientist

20083 201012,

物理系美国普度大学Research Scientist

20072 20082,

中国科学院武汉物理与数学研究所 (WIPM), 助理研究员

20027 20072,

中国科学院武汉物理与数学研究所 (WIPM), 博士学位

19989月– 20026,

武汉大学物理学基地班学士学位