我们很高兴邀请到美国韦恩州立大学储祥蔷教授来访，并做题为“利用中子散射和分子动力学模拟研究纳米金刚石表面和生物大分子的相互作用”的报告。报告时间为12月30日上午10：00至11：00，地点为科学楼902。
报告摘要：
Effect of Nanodiamond Surfaces on the Dynamics of Biomolecules Studied by Neutron Scattering and MD Simulations
Department of Physics and Astronomy, Wayne State University, USA
Nanodiamond (ND) inherits most of the superior properties of bulk diamond and delivers them at the nanoscale. Recent studies demonstrate that ND has excellent properties needed for the drug delivery platform, such as high biocompatibility, the ability to carry a broad range of therapeutics and release them in a controllable fashion, dispersability in water and scalability, and the potential for targeted therapy. Here we investigate the change in the tRNA dynamics on ND surfaces relative to the freestanding tRNA using neutron scattering technique and molecular dynamics (MD) Simulations. The dynamics of hydrated tRNA on ND surfaces are compared with that of freestanding hydrated tRNA molecules and dry tRNA on ND surfaces at the molecular level within the time range of picosecond to several nanoseconds. Both experiments and simulations show faster dynamics of tRNA on ND surface compared to that of the dry tRNA on ND surfaces or freestanding tRNA molecules, contrary to the generally held notion of slower dynamics at the interface.We attribute the faster motion to the weaker dynamic heterogeneity and swelling of the tRNA molecule on the ND surface, a consequence of strong interactions between the ND, tRNA, and water. Our study elucidates how ND surfaces can alter the functionality of biomolecules thereby providing new design principles for safer, improved drug delivery platforms.
References
[1] Mochalin, V. N.; Shenderova, O.; Ho, D.; Gogotsi, Y., The properties and applications of nanodiamonds. Nature Nanotechnology 2012, 7 (1), 11-23.
[2] Gurpreet K. Dhindsa, Debsindhu Bhowmik, Monojoy Goswami, Panchapakesan Ganesh, Vadym N. Mochalin, Hugh O’Neill, Yury Gogotsi, Eugene Mamontov, Bobby G. Sumpter, Liang Hong, and Xiang-qiang Chu*, Enhanced Dynamics of Hydrated RNA on Nanodiamond Surfaces, submitted, 2015.
[3] X.-Q. Chu*, E. Mamontov, H. O’Neill, and Q. Zhang, “Temperature Dependence of Logarithmic-like Relaxational Dynamics of Hydrated tRNA”, J. Phys. Chem. Lett. 4, 936-942 (2013).
储祥蔷，美国韦恩州立大学物理与天文系助理教授，博士生导师。2002和2005年分别于北京大学物理学院获得学士和硕士学位。2010年于美国麻省理工学院核科学与工程系获得博士学位，毕业后在美国橡树岭国家实验室进行博士后研究工作。2012年8月起被美国韦恩州立大学聘为终身制助理教授。主要研究兴趣包括利用中子散射和X射线散射以及分子动力学模拟研究生物大分子的结构和动力学性质，以及生物分子和纳米材料的相互作用。迄今为止已在国际知名期刊发表SCI论文二十余篇，包括PNAS, Physical Review Letters, Physical Review E, Journal of Physical Chemistry Letters, Journal of Physical Chemistry B, Soft Matter等。论文被引用500余次，h-index 11；研究成果曾被多家媒体报道。曾在美国物理学会年会等多个国际会议做邀请报告。担任Nature Communications, Journal of Physical Chemistry Letters, Chemical Physics, Biopolymers等期刊的审稿人。
